ABSTRACT
Background:Triple-negative breast cancer (TNBC) is a hostile sub-type consisting of nearly 10-20% of breast cancer patients. TNBC has been known to have a poor prognosis and overall survival (OS) compared to many other breast cancer tumors categories. These tumors are highly aggressive and have a higher risk of early recurrence. Nevertheless, no evidence exists to date and this is also the situation in Saudi Arabia. Recently, it was found to be a heterogeneous disease. Objective:To subtype breast cancer (BC) following the recent advance molecular classification, and to ascertain the correlation of those sub-types with pathological parameters and to study triple-negative breast cancer and its correlation with other subtypes and its association with recurrence and poor prognosis. Methods: The study was performed on 740 breast cancer patients at the Department of Pathology, King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom ofSaudi Arabia diagnosed between 2005 to 2018. The parameters like Estrogen receptor (ER), Progesterone receptor (PR), and human epidermal growth factor receptor immunostaining were analyzed semi-quantitatively to establish the HER-2, triple-negative, molecular subtypes of luminal A and B in paraffin-embedded sections of BC. We review the histopathology report, tumor invasion, grade, margin, type of surgery, recurrence, metastases, and survival rate. Results: The most common sub-types were luminal B (19.7%), followed by triple-negative breast cancer(10.9%) and HER2-positive (9.5%), whereasluminal A was the least common subtype (8.1 %). In luminal A majority of their age less than or equal to 50 years, most of these subtypes have tumor invasion, 59.2% of triple-negative breast cancer had positive axillary lymph node involvement. 63.4 % of triple-negative breast cancer had grade 3 tumors most of the recurrence in luminal B. Conclusion: The biological behaviors of each molecular subtype is likely to be with characteristic pathological features. In addition to molecular sub-typing and further prognostic indicators, might be useful in investigating the prognosis and management of BC patients. The early diagnosis and screening of BC are recommended in our population
ABSTRACT
Aims: A ventral hernia is a protrusion of viscera through an abdominal wall defect. Ventral hernias are mostly treated by a surgical procedure called open ventral hernia repair (OVHR). However, complications arising from the OVHR procedure mayresult in the recurrence of a hernia.This study was aimed to measure the recurrence rate of ventral hernia after OVHR with mesh and the reasons for failure.Study Design:It was a cross-sectional retrospective study conducted on all patients who underwent an OVHR with mesh, between 2010 and 2017, at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia. Data were extracted from KAUH medical records. A total of 241 patients were included in the study, divided into two groups; group 1-patients with recurrence(37 patients) and group 2-patients with no recurrence(204 patients).Consent was taken from patientsand preoperative assessment of procedures were performed under general anesthesia. The variables in the study are parameters like age, sex, parity, and history of chronic liver disease and their correlation with recurrence of thehernia. Different variables Data were analyzed by SPSS v 21. Association between the variables was determined using the t-test and Pearson’s Chi-squared tests.Results:The relationship between recurrence and age was statistically significant (P=0.019). The recurrence of hernia was more frequent in females than males. Patients with a history of multiparity(P=0.00) and liver diseases (P=0.041) showed significant differences in terms of recurrence. The umbilical hernia was more prevalent (133 cases; 55.2%) than other types of hernia. The most frequent site of hernia in the recurrence group was supraumbilical(38.46%; P=0.039).Conclusion:OVHR is a commonly performed surgical procedure at KAUH. Because of multiparity, ventral hernia recurrence was more common in women than men. To reduce recurrences, we recommend doing exercises to strengthen the abdominal muscles. Patients with chronic liver diseases in the form of portal hypertension should avoid surgical repair. For the surgeons, the type of mesh does not have a significant impact on recurrence